ACV 1

Cat. No. 3205

Price and Availability

For ACV 1 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Conotoxin Vc1.1

Biological Activity

Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC₅₀ values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.

Licensing Information

Sold under license from Dr Bruce Livett

Technical Data

M.Wt:

1806.98

Formula:

C₇₁H₁₀₃N₂₃O₂₅S₄

Sequence:

GCCSDPRCNYDHPEIC

(Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Storage:

Store at -20°C

CAS No:

740980-24-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Sandall et al (2003) A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 6904. PMID: 12779345.

Vincler et al (2006) Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proc.Nat.Acad.Sci.USA 103 17880.

Nevin et al (2007) Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Mol.Pharmacol 72 1406. PMID: 17804600.

Halai et al (2009) Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor J.Biol.Chem. 284 20275. PMID: 19447885.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Acetylcholine Nicotinic Receptors

Nicotinic Receptors (Other Subtypes)

Keywords: ACV 1, supplier, α9α10, alpha9alpha10, selective, a9, a10, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, ACV1, ConotoxinVc11