R&D Systems Inc. Tocris Bioscience Boston Biochem

Colchicine

Cat. No. 1364

Colchicine C22H25NO6 [64-86-8]

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Chemical Name: (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

Biological Activity

Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.

Technical Data

M.Wt:
399.44
Formula:
C22H25NO6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
64-86-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Hastie (1991) Interactions of colchicine with tubulin. Pharmacol.Ther. 51 377. PMID: 1792241.

Burns (1992) Analysis of the colchicine-binding site of β-tubulin. FEBS Lett. 297 205. PMID: 1544399.

Bai et al (1996) Identification of cysteine 354 of β-tubulin as part of the binding site for the A ring of colchicine. J.Biol.Chem. 271 12639. PMID: 8647876.

If you know of a relevant citation for this product please let us know.

Keywords: Colchicine, supplier, Inhibitor, tubulin, Tau, Tubulin, Microtubules, Mitosis

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