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Camostat mesylate

Cat. No. 3193

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Chemical Name: 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate

Biological Activity

Orally active protease inhibitor. Known to inhibit trypsin and various inflammatory proteases including plasmin, kallikrein and thrombin. Suppresses pancreatitis-induced pain in rats following oral administration.

Technical Data

M.Wt:

494.52

Formula:

C₂₀H₂₂N₄O₅.CH₃SO₃H

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

59721-29-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Horiuchi et al (1990) Gabexate and camostat, synthetic proteinase inhibitors, as direct inducing factors of water and bicarbonate secretion in the isolated and blood-perfused dog pancreas. J.Pharmacol.Exp.Ther. 252 320. PMID: 1688943.

Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 80 1999. PMID: 17433371.

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