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MirinCat. No. 3190 |
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Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one |
Biological Activity
Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.Certificate of Analysis / Safety Data Sheet
References
Dupre et al (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 4 119. PMID: 18176557.
Stivers (2008) Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 4 86. PMID: 18202674.
Garner et al (2009) Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 5 129. PMID: 19219009.
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Keywords: Mirin, supplier, MRN-ATM, pathway, inhibitors, exonuclease, activity, Mre11-Rad50-Nbs1, Esterases, ATM, activation
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