MirinCat No. 3190 |
Price and Availability |
|
Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-on e |
|
Biological Activity
Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Dupre et al (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 4 119. Stivers (2008) Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 4 86. Garner et al (2009) Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 5 129.If you know of a useful citation for this product please let us know.
View Related Products by Target
Keywords: Mirin, MRN-ATM, pathway, inhibitors, exonuclease, activity, Mre11-Rad50-Nbs1, Esterases, ATM, activation
Buy Now / Print Quote
Find multiple products by catalog number
Print Quote Facility
Order via your purchasing department
It's now even easier to place orders via your purchasing department.
Simply add a product to your cart & click on the "Print Quote" button.
Cancer Research Guide
Highlights over 400 products for cancer research. Request a copy or view PDF today.
Kinase Research Guide
Highlights over 220 products for kinase research. Request a copy or view PDF today.
Kinase Inhibitor Toolbox
80 Kinase inhibitors
pre-dissolved in DMSO
Some of the most potent
kinase inhibitors all on one plate
Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.
New Products in this Area
Hdm2 inhibitor; activates p53-dependent transcription
SJ 172550MDMX inhibitor. Disrupts MDMX-p53 interaction
INH1Hec1 inhibitor; causes arrest of mitosis
Cyclic Pifithrin-α hydrobromidep53 inhibitor
Careers at Tocris
Tocris Bioscience currently has opportunities for a Chemistry Technician.
If you would like to be considered for any positions not currently advertised, we welcome your speculative application.
