Cat. No. 3190
Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-
Biological ActivityMre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Dupre et al (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 4 119. PMID: 18176557.
Stivers (2008) Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 4 86. PMID: 18202674.
Garner et al (2009) Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 5 129. PMID: 19219009.
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Keywords: Mirin, supplier, MRN-ATM, pathway, inhibitors, exonuclease, activity, Mre11-Rad50-Nbs1, Esterases, ATM, activation
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