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MirinCat No. 3190 |
Price and Availability |
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Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-on e |
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Biological Activity
Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.Technical Data
M.Wt:220.25
Formula:C10H8N2O2S
Solubility:Soluble to 100 mM in DMSO
Purity: >99 %
Storage:Store at +4°C
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch
For specific/earlier batch please select:
References
Dupre et al (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 4 119. Stivers (2008) Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 4 86. Garner et al (2009) Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 5 129.If you know of a useful citation for this product please let us know.
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Keywords: Mirin, MRN-ATM, pathway, inhibitors, exonuclease, activity, Mre11-Rad50-Nbs1, Esterases, ATM, activation
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