R&D Systems Inc. Tocris Bioscience Boston Biochem

Mirin

Cat. No. 3190

Mirin C10H8N2O2S [1198097-97-0]

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Chemical Name: Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one

Biological Activity

Mre11-Rad50-Nbs1 (MRN)-ATM pathway inhibitor that blocks the 3' and 5' exonuclease activity associated with Mre11. Prevents ATM activation in response to double strand breaks (IC50 = 12 μM) and induces G2 cell cycle arrest. Also blocks homology-directed repair in vitro.

Technical Data

M.Wt:
220.25
Formula:
C10H8N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1198097-97-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Dupre et al (2008) A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 4 119. PMID: 18176557.

Stivers (2008) Small molecule versus DNA repair mechanisms. Nat.Chem.Biol. 4 86. PMID: 18202674.

Garner et al (2009) Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat.Chem.Biol. 5 129. PMID: 19219009.

If you know of a relevant citation for this product please let us know.

Keywords: Mirin, supplier, MRN-ATM, pathway, inhibitors, exonuclease, activity, Mre11-Rad50-Nbs1, Esterases, ATM, activation

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