Cat. No. 3131
Chemical Name: 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone hydrochloride
Biological ActivityNon-competitive NMDA receptor antagonist (EC50 values are 13.6 and 17.6 μM for NR1/NR2A and NR1/NR2B subunit combinations respectively). Dissociative anesthetic. S-enantiomer (Cat. No. 4379) also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Anis et al (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br.J.Pharmacol. 79 565. PMID: 6317114.
Pallares et al (1995) Effects of ketamine, a noncompetitive NMDA antagonist, on the acquisition of the lever-press response in rats. Physiol.Behav. 57 389. PMID: 7716221.
Liu et al (2001) Modulation of NMDA receptor function by ketamine and magnesium: part I. Anesth.Pharmacol. 92 1173.
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Keywords: Ketamine hydrochloride, supplier, Non-competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Dissociative, anesthetic
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