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α-Conotoxin EI

Cat. No. 3124

a-Conotoxin EI Arg-Asp-Hyp-Cys-Cys-Tyr-His-Pro-Thr-Cys-Asn-Met-Ser-Asn-Pro-Gln-Ile-Cys-NH2

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Biological Activity

Selective antagonist of neuromuscular nicotinic receptors α1β1γδ. Displays selectivity for α/δ sites over α/γ sites in Torpedo.

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:

2093.4

Formula:

C₈₃H₁₂₅N₂₇O₂₇S₅

Sequence:

RDXCCYHPTCNMSNPQIC

(Modifications: X = Hyp, Cys-18 = C-terminal amide, Disulfide bridge between 4 - 10, 5 - 17)

Solubility:

Soluble to 2 mg/ml in 10% acetonitrile

Storage:

Store at -20°C

CAS No:

170663-33-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Martinez et al (1995) α-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry 34 14519. PMID: 7578057.

Park et al (2001) Solution conformation of α-Conotoxin EI, a neuromuscular toxin specific for the α1/δ subunit interface of Torpedo nicotinic acetylcholine receptor. J.Biol.Chem. 276 49028. PMID: 11641403.

Lopez-Vera et al (2007) Novel α-conotoxins from Conus spurius and the α-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS Lett. 274 3972.

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