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α-Conotoxin PnIA

Cat. No. 3123

a-Conotoxin PnIA Gly-Cys-Cys-Ser-Leu-Pro-Pro-Cys-Ala-Ala-Asn-Asn-Pro-Asp-Tyr-Cys-NH2

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Biological Activity

Selective antagonist of α3β2 nAChR receptors (IC₅₀ values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:

1622.82

Formula:

C₆₅H₉₅N₁₉O₂₂S₄

Sequence:

GCCSLPPCAANNPDYC

(Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Solubility:

Soluble to 5 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

705300-84-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Fainzilber et al (1994) New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 33 9523. PMID: 8068627.

Luo et al (1999) Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38 14542. PMID: 10545176.

Everhart et al (2003) Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 306 664. PMID: 12734390.

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