α-Conotoxin PnIACat No. 3123 |
Price and Availability |
Biological Activity
Selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).Licensing Information
Sold under license from University of Utah.Technical Data
M.Wt:(Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Certificate of Analysis / MSDS
References
Fainzilber et al (1994) New mollusc-specific a-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 33 9523. Luo et al (1999) Single-residue alteration in a-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38 14542. Everhart et al (2003) Identification of residues that confer a-conotoxin-PnIA sensitivity on the a3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 306 664.If you know of a useful citation for this product please let us know.
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Keywords: a-Conotoxin PnIA, Selective, α3β2, alpha3beta2, a3b2, nAChR, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, α-conotoxin, alpha-conotoxin, PnIA
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Modulators of Peripheral Sensitization
Written by M.R. Vasko and G.D. Nicol
'Pharmacological Modulators of Peripheral Sensitization' summarizes the inhibitory and excitatory modulators of peripheral sensitization.
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