Cat. No. 3121
Biological ActivitySelective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
Licensing InformationSold under license from University of Utah
(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445. PMID: 13679412.
Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]Dopamine release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231. PMID: 15316087.
Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990.
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Keywords: a-Conotoxin PIA, supplier, Selective, antagonists, a6, α6, alpha6, containing, nicotinic, receptors, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, PIA, a-ConotoxinPIA, conotoxin
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