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α-Conotoxin PIA

Cat. No. 3121

a-Conotoxin PIA Arg-Asp-Pro-Cys-Cys-Ser-Asn-Pro-Val-Cys-Thr-Val-His-Asn-Pro-Gln-Ile-Cys-NH2

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Biological Activity

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC₅₀ values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:

1981.3

Formula:

C₇₉H₁₂₅N₂₇O₂₅S₄

Sequence:

RDPCCSNPVCTVHNPQIC

(Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18)

Solubility:

Soluble to 2 mg/ml in 10% acetonitrile

Storage:

Store at -20°C

CAS No:

669050-68-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445. PMID: 13679412.

Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [³H]Dopamine release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231. PMID: 15316087.

Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990.

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