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α-Conotoxin AuIB

Cat. No. 3120

a-Conotoxin AuIB Gly-Cys-Cys-Ser-Tyr-Pro-Pro-Cys-Phe-Ala-Thr-Asn-Pro-Asp-Cys-NH2

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Biological Activity

Selective antagonist of α3β4 nicotinic acetylcholine receptors. Displays > 100-fold selectivity over other receptor subunit combinations including α2β2, α2β4, α3β2, α4β2, α4β4 and α1β1γδ.

Licensing Information

Sold under license from University of Utah

Technical Data

M.Wt:

1572.76

Formula:

C₆₅H₈₉N₁₇O₂₁S₄

Sequence:

GCCSYPPCFATNPDC

(Modifications: Cys-15 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 15)

Solubility:

Soluble to 5 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

216299-21-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Luo et al (1998) α-Conotoxin AuIB selectively blocks α3β4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release. J.Neurosci. 18 8571. PMID: 9786965.

Nai et al (2003) Relating neuronal nicotinic acetylcholine receptor subtypes defined by subunit composition and channel function. Mol.Pharmacol. 63 311. PMID: 12527802.

Park et al (2006) An α3β4 subunit combination acts as a major functional nicotinic acetylcholine receptor in male rat pelvic ganglion neurons. Pflugers Arch. 452 775. PMID: 16715294.

If you know of a relevant citation for this product please let us know.

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