Cat. No. 3110
Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrr
Biological ActivityMajor metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931. PMID: 12706481.
Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229. PMID: 16389292.
O'Leary et al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646. PMID: 18305015.
Echeverria et al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1. PMID: 20930295.
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Keywords: Cotinine, supplier, metabolite, nicotine, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR, Nicotinic Receptor (Non-selective) Agonists
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