R&D Systems Inc. Tocris Bioscience Boston Biochem

(-)-Cotinine

Cat. No. 3110

Cotinine C10H12N2O [486-56-6]

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Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone

Biological Activity

Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.

Technical Data

M.Wt:
176.22
Formula:
C10H12N2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
486-56-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931. PMID: 12706481.

Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229. PMID: 16389292.

O'Leary et al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646. PMID: 18305015.

Echeverria et al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1. PMID: 20930295.

If you know of a relevant citation for this product please let us know.

Keywords: Cotinine, supplier, metabolite, nicotine, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, nAChR

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