Home » Pharmacology » Ion Channels » Ligand-gated Ion Channels » Acetylcholine Nicotinic Receptors » Nicotinic Receptors (Non-selective) » (-)-Cotinine

(-)-Cotinine

Cat. No. 3110

Price and Availability

For (-)-Cotinine pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone

Biological Activity

Major metabolite of nicotine. Shown to activate a subpopulation of α3/α6β2 nAChRs in monkey striatum. Displays cognition-enhancing effects in vivo; reduces amyloid β (Aβ) aggregation and improves memory in an Alzheimer's disease mouse model.

Technical Data

M.Wt:

176.22

Formula:

C₁₀H₁₂N₂O

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

486-56-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Buccafusco and Terry (2003) The potential role of cotinine in the cognitive and neuroprotective actions of nicotine. Life Sci. 72 2931. PMID: 12706481.

Terry et al (2005) Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev. 11 229. PMID: 16389292.

O'Leary et al (2008) Cotinine selectively activates a subpopulation of α3/α6β2 nicotinic receptors in monkey striatum. 325 646. PMID: 18305015.

Echeverria et al (2011) Cotinine reduces amyloid-β aggregation and improves memory in Alzheimer's disease mice. J.Alzheimers Dis. 23 1. PMID: 20930295.

If you know of a relevant citation for this product please let us know.