R&D Systems Inc. Tocris Bioscience Boston Biochem

PU H71

Cat. No. 3104

PU H71 C18H21IN6O2S [873436-91-0]

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Chemical Name: 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine

Biological Activity

Potent inhibitor of heat shock protein 90 (Hsp90) (IC50 = 51 nM in MDA-MB-468 cells). Also inhibits cell growth in a range of breast cancer cell lines (IC50 values are 17, 31, 65, 87 and 140 nM for SKBr3, MCF-7, MDA-MB-468, HCC-1806 and MDA-MB-231 cells respectively). Shown to inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.

Technical Data

M.Wt:
512.37
Formula:
C18H21IN6O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
873436-91-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

He et al (2006) Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J.Med.Chem. 49 381. PMID: 16392823.

Chan et al (2008) Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. Cancer Res. 68 216. PMID: 18172314.

Caldas-Lopes et al (2009) Hsp90 inhibitor, PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc.Natl.Acad.Sci.USA 106 8368. PMID: 19416831.

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Keywords: PU H71, supplier, PUH71, heat, shock, proteins, hsp90, inhibitors, inhibits, potent

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