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XRP44X

Cat No. 3101

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Chemical Name: 1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-y l)carbonyl]piperazine

Biological Activity

Ras-Net (Elk-3) pathway inhibitor (IC₅₀ = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G₂-M cell cycle arrest, suppresses growth of multiple cell types (IC₅₀ ~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.

Technical Data

M.Wt:

380.87

Formula:

C₂₁H₂₁ClN₄O

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

>99 %

Storage:

Store at RT

CAS No:

[729605-21-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Wasylyk et al (2008) Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 68 1275.

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Keywords: XRP44X, Ras-Net, pathway, inhibitors, Antiangiogenics, microtubule, depolymerization, depolymerisation, agent, MAPK, Signaling, Signalling, G, Proteins, Small, Mitogen-Activated, Protein, Kinases, Tau, Tubulin