Cat. No. 3101
Chemical Name: 1-(3-Chlorophenyl)-4-[(3-methyl-1-p
Biological ActivityRas-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest, suppresses growth of multiple cell types (IC50 ~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Wasylyk et al (2008) Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 68 1275. PMID: 18316589.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: XRP44X, supplier, Ras-Net, pathway, inhibitors, Antiangiogenics, microtubule, depolymerization, depolymerisation, agent, MAPK, Signaling, Signalling, G, Proteins, Small, Mitogen-Activated, Protein, Kinases, Tau, Tubulin
Find multiple products by catalog number
New Products in this Area
Mnk1 and Mnk2 inhibitorAL 8697
Potent and selective p38α inhibitorDBM 1285 dihydrochloride
p38 MAPK inhibitor; anti-inflammatorySR 3576
Highly potent and selective JNK3 inhibitor
November 15 - 19, 2014
Washington D.C., USA