Cat. No. 3097
Biological ActivityBacterial toxin that catalyzes ADP-ribosylation of G-proteins Gi, Go and Gt. Impairs G protein heterotrimer interaction with receptors, blocking receptor coupling.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Bokoch et al (1983) Indentification of the predominant substrate for ADP-ribosylation by islet activating protein. J.Biol.Chem. 258 2072. PMID: 6296122.
Barbieri and Cortina (1988) ADP-ribosyltransferase mutations in the catalytic S-1 subunit of pertussis toxin. Infect.Immun. 56 1934. PMID: 3135265.
Casey et al (1989) G protein βγ subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of a subunits by pertussis toxin but differential interactions with Gsa. Biochemistry 28 611. PMID: 2496748.
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Keywords: Pertussis Toxin, supplier, Catalyzes, ADP-ribosylation, G-Protein, Heterotrimeric, Gi, Go, Gt, toxin