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FR 236924

Cat. No. 3091

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Alternative Name: DCP-LA

Chemical Name: 2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid

Biological Activity

Selective PKCε activator that displays > 7-fold selectivity over other PKC isozymes. Stimulates glutamate release via presynaptic α7 nicotinic receptors on glutamatergic terminals in vitro and enhances cognition in vivo. Brain penetrant.

Technical Data

M.Wt:

308.5

Formula:

C₂₀H₃₆O₂

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

28399-31-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Tanaka and Nishizaki (2003) The newly synthesized linoleic acid derivative FR236924 induces a long lasting facilitation of hippocampal neurotransmission by targeting nicotinic acetylcholine receptors. Bioorg.Med.Chem.Letts. 13 1037.

Yamamoto et al (2005) The linoleic acid derivative FR236924 facilitates hippocampal synaptic transmission by enhancgng activity of presynaptic α7 acetylcholine receptors on the glutamatergic terminals. Neuroscience 130 207. PMID: 15561436.

Kanno et al (2006) The linoleic acid derivative DCP-LA selectively activates PKC-ε, possibly binding to the phosphatidylserine binding site. J.Lipid Res. 47 1146. PMID: 16520488.

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Keywords: FR 236924, supplier, pkc, pkce, epsilon, protein, kinase, c, a7, α7, alpha7, nAChR, nicotinic, acetylycholine, receptor, ACh, FR236924

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