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HU 308

Cat. No. 3088

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Chemical Name: 4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol

Biological Activity

Potent and selective CB₂ receptor agonist (K_i values are 22.7 nM and > 10 μM for CB₂ and CB₁ receptors respectively, EC₅₀ = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain.

Licensing Information

Sold under license from Hebrew University of Jerusalem

Technical Data

M.Wt:

414.62

Formula:

C₂₇H₄₂O₃

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

256934-39-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Hanus et al (1999) HU-308: a specific agonist for CB₂, a peripheral cannabinoid receptor. Proc.Natl.Acad.Sci.USA 96 14228.

LaBuda et al (2005) Cannabinoid CB₂ receptor agonist activity in the hindpaw incision model of postoperative pain. Eur.J.Pharmacol. 527 172. PMID: 16316653.

Garcia-Arencibia et al (2007) Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties. Brain Res. 1134 162. PMID: 17196181.

If you know of a relevant citation for this product please let us know.

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