Etoposide

Cat. No. 1226

Etoposide C29H32O13 [33419-42-0]

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Chemical Name: [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-Ο-Ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-(5aH)-one

Biological Activity

Topoisomerase II inhibitor (IC50 = 59.2 μM).

Technical Data

M.Wt:
588.56
Formula:
C29H32O13
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
33419-42-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Terada et al (1993) Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents. J.Med.Chem. 36 1689. PMID: 8389875.

Burden et al (1996) Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J.Biol.Chem. 271 29238. PMID: 8910583.

Hande et al (1998) Etoposide: four decades of development of a topoisomerase II inhibitor. Eur.J.Cancer 34 1514. PMID: 9893622.

If you know of a relevant citation for this product please let us know.

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Keywords: Etoposide, supplier, Topoisomerase, II, inhibitors, DNA, Isomerases, VP16, Tocris Bioscience, DNA Topoisomerase Inhibitors

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