Cat. No. 1226
Chemical Name: [5R-[5α,5aβ,8aα,9β(R*)]]-9-[(4,6-0-Ethylidene-α-D-glucopyransoyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naptho[2,3-d]-1,3-dioxol-6-(5aH)-one
Biological ActivityTopoisomerase II inhibitor (IC50 = 59.2 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Terada et al (1993) Antitumor agents.3.Synthesis and biological activity of 4β-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents. J.Med.Chem. 36 1689. PMID: 8389875.
Burden et al (1996) Toposiomerase II.etoposide interactions direct the formation of drug-induced enzyme-DNA cleavage complexes. J.Biol.Chem. 271 29238. PMID: 8910583.
Hande et al (1998) Etoposide: four decades of development of a topoisomerase II inhibitor. Eur.J.Cancer 34 1514. PMID: 9893622.
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Keywords: Etoposide, supplier, Topoisomerase, II, inhibitors, DNA, Isomerases
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December 16, 2013