Cat. No. 1138

Thapsigargin C34H50O12 [67526-95-8]

Price and Availability

For Thapsigargin pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate

Biological Activity

Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

Technical Data

Soluble to 100 mM in DMSO
>97 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet


Davidson and Varhol (1995) Kinetics of thapsigargin-Ca2+-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition. J.Biol.Chem. 270 11731. PMID: 7744817.

Treiman et al (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. TiPS 19 131. PMID: 9612087.

Yu et al (1998) Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells. J.Biol.Chem. 273 3542. PMID: 9452480.

Ding et al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: Thapsigargin, supplier, Potent, inhibitor, SERCA, ATPase, Ca2+, modulators, Ca2+-ATPase, Signaling, Signalling, Calcium-ATPase, P-type, Transporters, Ion, Pumps, Ca2+-ATPase Inhibitors

Quick Order

Find multiple products by catalog number

divider line

New Product Guide


Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

Bio-Techne Events

One Day Symposium

Bio-Techne Symposium 2015

Stem Cells & Organoids as Models of Tissue Differentiation & Disease

January 12, 2016

London, UK