R&D Systems Inc. Tocris Bioscience Boston Biochem

BRL 44408 maleate

Cat. No. 1133

BRL 44408 maleate C13H17N3.C4H4O4 [681806-46-2]

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Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate

Biological Activity

Selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors respectively). Increases hippocampal noradrenalin release following systemic administration. Also available as part of the α2-Adrenoceptor Tocriset™.

Licensing Information

Sold with the permission of GlaxoSmithKline

Technical Data

M.Wt:
331.37
Formula:
C13H17N3.C4H4O4
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
681806-46-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Young et al (1989) Novel α2-adrenoceptor antagonists show selectivity for α2A- and α2B-adrenoceptor subtypes. Eur.J.Pharmacol. 168 381. PMID: 2573535.

Kiss et al (1995) Subtype-specificity of the presynaptic α2-adrenoceptors modulating hippocampal norepinephrine release in rat. Brain Res. 674 238. PMID: 7796102.

Gavin et al (1997) α2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch.Pharmacol. 355 406. PMID: 9089673.

Callado et al (1999) α2A-But not α2B/C-adrenoceptors modulate noradrenaline release in rat locus coeruleus: voltammetric data. Eur.J.Pharmacol. 366 35. PMID: 10064149.

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Keywords: BRL 44408 maleate, supplier, Selective, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-Adrenergic, a2a-adrenergic, antagonists, Receptors, BRL44408, maleate, GlaxoSmithKline, GSK

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