R&D Systems Inc. Tocris Bioscience Boston Biochem

8-Bromo-cGMP, sodium salt

Cat. No. 1089

8-Bromo-cGMP, sodium salt C10H10BrN5NaO7P [51116-01-9]

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Chemical Name: 8-Bromoguanosine cyclic 3',5'-monophosphate sodium salt

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.

Technical Data

M.Wt:
446.09
Formula:
C10H10BrN5NaO7P
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
51116-01-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ignarro et al (1974) Stimulation of phagocytic release of neutral protease from human neutrophils by cholinergic amines and cyclic 3',5'-guanosine monophosphate. J.Immunol. 112 210. PMID: 4359834.

Buchan et al (1991) Modulation of agonist-induced calcium mobilisation in bovine aortic endothelial cells by phorbol myristate acetate and cyclic AMP but not cyclic GMP. Br.J.Pharmacol. 104 361. PMID: 1665733.

Sekhar et al (1992) Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type 1α, compared with type 1β, cGMP-dependent protein kinase. Mol.Pharmacol. 42 103. PMID: 1321950.

If you know of a relevant citation for this product please let us know.

Keywords: 8-Bromo-cGMP, sodium salt, supplier, cGMP, analog, activates, PKG, protein, kinase, G, activator

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