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Zolpidem

Cat. No. 0655

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Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide

Biological Activity

Benzodiazepine agonist with high selectivity for α1-subunit-containing GABA_A receptors (BZ/ω₁ site) and very high intrinsic activity. K_i values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABA_A receptors respectively. Hypnotic that does not induce physical dependence.

Technical Data

M.Wt:

307.39

Formula:

C₁₉H₂₁N₃O

Solubility:

Soluble to 100 mM in ethanol and to 50 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

82626-48-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Arbilla et al (1986) High affinity [³H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257. PMID: 2878820.

Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649. PMID: 2871178.

Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J.Pharmacol.Exp.Ther. 263 298. PMID: 1403792.

Crestani et al (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br.J.Pharmacol. 131 1251. PMID: 11090095.

If you know of a relevant citation for this product please let us know.

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