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Y-25130 hydrochloride

Cat No. 0380

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Special Conditions

Not for sale in Japan.

Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo -3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

Biological Activity

A selective and potent 5-HT₃ antagonist (K_i = 2.9 nM).

Technical Data

M.Wt:

386.28

Formula:

C₁₇H₂₀ClN₃O₃.HCl

Solubility:

Soluble to 100 mM in water and to 10 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at -20°C

CAS No:

[123040-16-4]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT₃ receptor antagonist. Eur.J.Pharmacol. 196 299. Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443. Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin(3) receptor antagonist on chemotherapeutic agent-induced emesis. Jap.J.Pharmacol. 63 377.

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