R&D Systems Inc. Tocris Bioscience Boston Biochem

Y-25130 hydrochloride

Cat. No. 0380

Y-25130 hydrochloride C17H20ClN3O3.HCl [123040-16-4]

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Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

Biological Activity

A selective and potent 5-HT3 antagonist (Ki = 2.9 nM).

Technical Data

M.Wt:
386.28
Formula:
C17H20ClN3O3.HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
123040-16-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299. PMID: 1654255.

Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443. PMID: 1331590.

Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377. PMID: 8107329.

If you know of a relevant citation for this product please let us know.

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Keywords: Y-25130 hydrochloride, supplier, Potent, selective, 5-HT3, antagonists, Serotonin, Receptors

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