Y-25130 hydrochloride

Cat. No. 0380

Y-25130 hydrochloride C17H20ClN3O3.HCl [123040-16-4]

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Chemical Name: N-(1-Azabicyclo[2.2.2]oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride

Biological Activity

A selective and potent 5-HT3 antagonist (Ki = 2.9 nM).

Technical Data

M.Wt:
386.28
Formula:
C17H20ClN3O3.HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
123040-16-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Fukuda et al (1991) The antiemetic profile of Y-25130, a new selective 5-HT3 receptor antagonist. Eur.J.Pharmacol. 196 299. PMID: 1654255.

Sato et al (1992) Antagonistic activity of Y-25130 on 5-HT3 receptors. Jpn.J.Pharmacol. 59 443. PMID: 1331590.

Haga et al (1993) The effects of orally administered Y-25130, a selective serotonin3 receptor antagonist on chemotherapeutic agent-induced emesis. Jpn.J.Pharmacol. 63 377. PMID: 8107329.

If you know of a relevant citation for this product please let us know.

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Keywords: Y-25130 hydrochloride, supplier, Potent, selective, 5-HT3, antagonists, Serotonin, Receptors, Tocris Bioscience, 5-HT3 Receptor Antagonists

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