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ω-Conotoxin GVIA

Cat. No. 1085

w-Conotoxin GVIA Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH2 (Disulfide bridges: 1 - 16, 8 - 19, 15 - 26)

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Biological Activity

Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels.

Technical Data

M.Wt:

3037

Formula:

C₁₂₀H₁₈₈N₃₈O₄₃S₆

Sequence:

CKSXGSSCSXTSYNCCRSCNXYTKRCY

(Modifications: X = Hyp, Disulfide bridge between 1 - 16, 8 - 19, 15 - 26, Tyr-27 = C-terminal amide)

Solubility:

Soluble to 0.25 mg/ml in 20% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

106375-28-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Tsien et al (1988) Multiple types of neuronal calcium channels and their selective modulation. TiNS 11 431. PMID: 2469160.

Casali et al (1997) Different effects of reducing agents on ω-conotoxin GVIA inhibition of [³H]-acetylcholine release from rat cortical slices and guinea-pig myenteric plexus. Br.J.Pharmacol. 120 88. PMID: 9117104.

Wright and Angu (1997) Prolonged cardiovascular effects of the N-type Ca²⁺ channel antagonist ω-conotoxin GVIA in conscious rabbits. J.Cardiovasc.Pharmacol. 30 392. PMID: 9300325.

If you know of a relevant citation for this product please let us know.

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Keywords: w-Conotoxin GVIA, supplier, Ca2+, channel, blockers, N-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, omega-Conotoxin, ω-conotoxin, GVIA, neurotoxins

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