Cat. No. 0619
Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)
Biological ActivityPotent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC50 values are 42, 6 and > 100 μM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.
Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442. PMID: 10454524.
Tomlins et al (2005) Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp.Cell Res. 308 439. PMID: 15950968.
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Keywords: AG 494, supplier, Potent, EGFR, kinase, inhibitors, Epidermal, Growth, Factors, Receptors, ErbB, Her, Tyrosine, Kinases, RTKs, AG494, Tocris Bioscience, EGFR Inhibitors
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March 19 - 23, 2016
Denver, CO, USA