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AG 494

Cat. No. 0619

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Chemical Name: (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-2-propenamide

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC₅₀ = 0.7 μM). Selective over ErbB2, PDGFR and insulin receptor kinase (IC₅₀ values are 42, 6 and > 100 μM respectively).

Technical Data

M.Wt:

280.28

Formula:

C₁₆H₁₂N₂O₃

Solubility:

Soluble to 5 mM in ethanol and to 50 mM in DMSO

Storage:

Desiccate at +4°C

CAS No:

133550-35-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Gazit et al (1991) Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J.Med.Chem. 34 1896. PMID: 1676428.

Ben-Bassat et al (1999) Tyrphostins that suppress the growth of human papilloma virus 16-immortalized human keratinocytes. J.Pharmacol.Exp.Ther. 290 1442. PMID: 10454524.

Tomlins et al (2005) Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp.Cell Res. 308 439. PMID: 15950968.

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