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1-Naphthyl PP1Cat. No. 3063 |
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Alternative Name: 1-NA-PP 1 Chemical Name: 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
Biological Activity
Selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl. (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).Certificate of Analysis / Safety Data Sheet
References
Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627.
Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395. PMID: 11014197.
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Keywords: 1-Naphthyl PP1, supplier, Src, family, kinase, inhibits, inhibitors, c-Abl, v-Src, c-Fyn, 1-NaphthylPP1, 1NAPP1
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