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AA 2414

Cat. No. 3025

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Alternative Name: Seratrodast

Chemical Name: 7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid

Biological Activity

Thromboxane A₂ (TP) receptor antagonist. Antiasthmatic agent; inhibits platelet aggregation and bronchoconstriction induced by a TXA₂ mimetic in guinea pigs.

Technical Data

M.Wt:

354.44

Formula:

C₂₂H₂₆O₄

Solubility:

Soluble to 75 mM in 1.1eq. NaOH and to 100 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

112665-43-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Ashida et al (1989) A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. Prostaglandins 38 91. PMID: 2748922.

Kurokawa et al (1994) Antagonism of the human thromboxane A₂ receptor by an anti-asthmatic agent AA-2414. Biol.Pharm.Bull. 17 383. PMID: 8019502.

Cui et al (2007) Leukotrienes and cyclooxygenase products mediate anaphylactic venoconstriction in ovalbumin sensitized rat livers. Eur.J.Pharmacol. 576 99. PMID: 17706964.

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