Cat. No. 1409
Chemical Name: (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid ethyl ester
Biological ActivityPotent, selective and competitive NMDA antagonist (Ki = 310 nM for inhibition of [3H]-CPP binding in rat brain). Centrally active upon oral administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Fagg et al (1990) CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-asparate receptor antagonists with oral activity. Br.J.Pharmacol. 99 791. PMID: 1972895.
Loscher and Honack (1991) Anticonvulsant and behavioural effects of two novel competitive N-methyl-D-aspartic acid receptor antagonists, CGP 37849 and CGP 39551, in the kindling model of epilepsy. Comparison with MK-801 and carbamazepine. J.Pharmacol.Exp.Ther. 256 432. PMID: 1671593.
D'Hooge et al (1999) Effects of competitive NMDA receptor antagonists on excitatory amino-acid-evoked currents in mouse spinal cord. Fundam.Clin.Pharmacol. 13 67. PMID: 10027090.
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Keywords: CGP 39551, supplier, Potent, selective, competitive, NMDA, antagonist, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, CGP39551
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