Home » Research Area » Endocrinology » Obesity Research | Endocrinology Research » 7-TM Receptors » 5-HT Receptors » 5-HT₂ Receptors » 5-HT_2C Receptors » SB 228357

SB 228357

Cat. No. 1375

Price and Availability

For SB 228357 pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide

Biological Activity

5-HT_2C/2B receptor antagonist (pK_i values are 7.0, 8.1 and 9.1 at 5-HT_2A, _2B and _2C receptors respectively). Displays inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT_2C receptor function. Orally active in vivo.

Licensing Information

Sold under license

Technical Data

M.Wt:

431.39

Formula:

C₂₂H₁₇F₄N₃O₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

181629-93-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Reavill et al (1999) Attenuation of haloperidol-induced catalepsy by a 5-HT_2C receptor antagonist. Br.J.Pharmacol. 126 572. PMID: 10188965.

Bromidge et al (2000) Biarylcarbamoylindolines are novel and selective 5-HT_2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J.Med.Chem. 43 1123. PMID: 10737744.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

5-HT₂ Receptors 5-HT_2B Receptors

5-HT_2C Receptors

Keywords: SB 228357, supplier, 5-HT2C, 5-HT2B, antagonists, inverse, agonists, Serotonin, Receptors, SB228357

Quick Order

Find multiple products by catalog number

5-HT Review

Written by Nicholas Barnes and John Neumaier, leading experts. Request a copy or view PDF today.

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

Neurobiology of Parkinson's Disease

Written by A. Schapira

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and summarizes current and novel therapeutic interventions.