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Levcromakalim

Cat. No. 1378

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Alternative Name: BRL 38227

Chemical Name: (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile

Biological Activity

Active enantiomer of the prototypical K_ir6 (K_ATP) channel opener cromakalim (Cat. No. 1377). Hypotensive and airways relaxant. IC₅₀ = 490 nM in guinea pig trachea.

Licensing Information

Sold under license

Technical Data

M.Wt:

286.33

Formula:

C₁₆H₁₈N₂O₃

Solubility:

Soluble to 10 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

94535-50-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Buckle et al (1991) Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols. J.Med.Chem. 34 919. PMID: 2002472.

Noack et al (1992) Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227). Br.J.Pharmacol. 107 945. PMID: 1467843.

Taylor et al (1992) The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways. J.Pharmacol.Exp.Ther. 261 429. PMID: 1578358.

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