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NF 279

Cat. No. 1199

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Chemical Name: 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt

Biological Activity

A potent and selective P2X₁ antagonist (IC₅₀ = 19 nM). Displays good selectivity over P2X₂,(IC₅₀ = 0.76 μM), P2X₃ (IC₅₀ = 1.62μM), P2X₄ (IC₅₀ > 300 μM), P2Y receptors and ecto-nucleotidases.

Technical Data

M.Wt:

1401.1

Formula:

C₄₉H₃₀N₆Na₆O₂₃S₆

Solubility:

Soluble to 25 mM in water

Storage:

Desiccate at -20°C

CAS No:

202983-32-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Damer et al (1998) NF279: a novel potent and selective antagonist of P2X receptor-mediated responses. Eur.J.Pharmacol. 350 R5. PMID: 9683026.

Klapperstuck et al (2000) Antagonism by the suramin analogue NF 279 on human P2X₁ and P2X₇ receptors. Eur.J.Pharmacol. 387 245. PMID: 10650169.

Rettinger et al (2000) The suramin analogue NF279 is a novel and potent antagonist selective for the P2X₁ receptor. Neuropharmacology 39 2044. PMID: 10963748.

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