R&D Systems Inc. Tocris Bioscience Boston Biochem

Oleamide

Cat. No. 0878

Oleamide C18H35NO [301-02-0]

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Chemical Name: cis-9-Octadecenamide

Biological Activity

Endogenous sleep-inducing lipid. Acts as an agonist at the CB1 cannabinoid receptor (EC50 = 1.64 μM). Also appears to potentiate the actions of 5-HT on 5-HT2A and 2C receptors, and act via an allosteric regulatory site on 5-HT7 receptors.

Technical Data

M.Wt:
281.48
Formula:
C18H35NO
Solubility:
Soluble to 100 mM in ethanol and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
301-02-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Cravatt et al (1995) Chemical characterisation of a family of brain lipids that induces sleep. Science 268 1506. PMID: 7770779.

Huidobro-Toro and Harris (1996) Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc.Natl.Acad.Sci.U.S.A. 93 8078. PMID: 8755606.

Hedlund et al (1999) Allosteric regulation by oleamide of the binding properties of 5-hydroxytryptamine7 receptors. Biochem.Pharmacol. 58 1807. PMID: 10571256.

Leggett et al (2004) Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors. Br.J.Pharmacol. 141 253. PMID: 14707029.

If you know of a relevant citation for this product please let us know.

Keywords: Oleamide, supplier, Sleep-inducing, brain, lipid, Potentiator, 5-HT2A, 5-HT2C, receptors, CB1, agonists, Lipid, Metabolism, Serotonin, 5-Hydroxytryptamine, Cannabinoid, cb1r

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