Cat. No. 0593

NPPB C16H16N2O4 [107254-86-4]

Price and Availability

For NPPB pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid

Biological Activity

Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Wangemann et al (1986) Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflugers Arch. 407 S128. PMID: 2434915.

Keeling et al (1991) Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line. Biochim.Biophys.Acta 115 42. PMID: 1720331.

Kirkup et al (1996) Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br.J.Pharmacol. 117 175. PMID: 8825360.

Taniguchi et al (2008) 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology 82 245. PMID: 18818509.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: NPPB, supplier, Chloride, channel, blockers, Cl-, Channels

Quick Order

Find multiple products by catalog number

divider line

New Product E-alerts

Sign up for email updates from Tocris


Enter your email address below to sign up to receive our email updates:

divider line

New Products in this Area

PA 1 dihydrochloride

Photoswitchable ENaC blocker

GlyH 101

Reversible, voltage-dependent CFTR chloride channel blocker

QAQ dichloride

Photoswitchable Nav, Kv and Cav channel blocker

AAQ chloride

Photoswitchable Kv channel blocker


Mitochondria VDAC modulator; also Ferroptosis activator

Sign-up for new product e-alerts
divider line

Bio-Techne Events


Neuroscience 2015

October 17-21, 2015

Chicago, IL