R&D Systems Inc. Tocris Bioscience Boston Biochem

NPPB

Cat. No. 0593

NPPB C16H16N2O4 [107254-86-4]

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Chemical Name: 5-Nitro-2-(3-phenylpropylamino)benzoic acid

Biological Activity

Inhibits calcium-sensitive chloride currents (10 μM). Putative GPR35 agonist.

Technical Data

M.Wt:
300.31
Formula:
C16H16N2O4
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>99 %
Storage:
Store at RT
CAS No:
107254-86-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Wangemann et al (1986) Cl--channel blockers in the thick ascending limb of the loop of Henle. Structure-activity relationship. Pflugers Arch. 407 S128. PMID: 2434915.

Keeling et al (1991) Effects of NPPB (5-nitro-1-(3-phenylpropylamino)benzoic acid on chloride transport in intestinal tissues and the T84 cell line. Biochim.Biophys.Acta 115 42. PMID: 1720331.

Kirkup et al (1996) Investigation of the effects of 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB) on membrane currents in rat portal vein. Br.J.Pharmacol. 117 175. PMID: 8825360.

Taniguchi et al (2008) 5-nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist Pharmacology 82 245. PMID: 18818509.

If you know of a relevant citation for this product please let us know.

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Keywords: NPPB, supplier, Chloride, channel, blockers, Cl-, Channels

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