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DOI hydrochloride

Cat. No. 2643

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Alternative Name: (±)-2,5-Dimethoxy-4-iodoamphetamine hydrochloride

Chemical Name: 4-Iodo-2,5-dimethoxy-α-methylbenzeneethanamine hydrochloride

Biological Activity

Brain penetrant, mixed 5-HT_2A/5-HT_2C receptor agonist (K_i values are 0.7, 2.4 and 20 nM for 5-HT_2A, 5-HT_2C and 5-HT_2B receptors respectively). Reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Hallucinogenic agent. Acts via 5-HT_2A receptors to inhibit the inflammatory effects of tumor necrosis factor (TNF)-α.

Technical Data

M.Wt:

357.62

Formula:

C₁₁H₁₆INO₂.HCl

Solubility:

Soluble to 50 mM in water

Purity:

>98 %

Storage:

Store at RT

CAS No:

42203-78-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Nelson et al (1999) Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT_2A, 5-HT_2B and 5-HT_2C receptors. Naunyn-Schmied.Arch.Pharmacol. 359 1.

Monti and Jantos (2006) Effects of serotonin 5-HT_2A/2C receptor agonist DOI and of the selective 5-HT_2A or 5-HT_2C receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking in the rat. Eur.J.Pharmacol. 553 163. PMID: 17059817.

Yu et al (2008) Serotonin 5-hydroxytryptamine₂A receptor activation suppresses tumor necrosis factor-α-induced inflammation with extraordinary potency. J.Pharmacol.Exp.Ther. 327 316. PMID: 18708586.

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