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TenidapCat. No. 2580 |
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Alternative Name: CP 66248 Chemical Name: 5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide |
Biological Activity
NSAID that preferentially inhibits COX-1 (IC50 values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hKir2.3 channel (EC50 = 402 nM).Certificate of Analysis / Safety Data Sheet
References
Moilanen et al (1988) CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids 1 35. PMID: 2856170.
Kirchner et al (1997) Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther. 282 1094. PMID: 9262379.
Liu et al (2002) Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3. Eur.J.Pharmacol. 435 153. PMID: 11821021.
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Keywords: Tenidap, supplier, NSAID, cyclooxygenase, COX-1, inhibitors, KIR23, openers, Cyclooxygenase, Oxygenases, Oxidases, Potassium, KIR, Channels, KATP, Inward, Rectifier, K+, CP66248
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