Home » Research Area » » Ion Channels » Potassium Channels » Inward Rectifier Potassium (K_ir) Channels » Tenidap

Tenidap

Cat. No. 2580

Price and Availability

For Tenidap pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: CP 66248

Chemical Name: 5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide

Biological Activity

NSAID that preferentially inhibits COX-1 (IC₅₀ values are < 0.03, 1.2 and > 30 μM for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK_ir2.3 channel (EC₅₀ = 402 nM).

Technical Data

M.Wt:

320.75

Formula:

C₁₄H₉N₂O₃SCl

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

120210-48-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Moilanen et al (1988) CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. Eicosanoids 1 35. PMID: 2856170.

Kirchner et al (1997) Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J.Pharmacol.Exp.Ther. 282 1094. PMID: 9262379.

Liu et al (2002) Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K⁺ channel hKir2.3. Eur.J.Pharmacol. 435 153. PMID: 11821021.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Cyclooxygenase Inward Rectifier Potassium (K_ir) Channels

Oxygenases/Oxidases Potassium Channels

Keywords: Tenidap, supplier, NSAID, cyclooxygenase, COX-1, inhibitors, KIR23, openers, Cyclooxygenase, Oxygenases, Oxidases, Potassium, KIR, Channels, KATP, Inward, Rectifier, K+, CP66248