Home » Pharmacology » 7-TM Receptors » Peptide Receptors » KISS-Derived Peptide (KISS1) Receptors » Kisspeptin 10 (human)

Kisspeptin 10 (human)

Cat. No. 2570

Price and Availability

For Kisspeptin 10 (human) pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Metastin (45-54), Kp-10

Biological Activity

Potent endogenous ligand for the KISS1 receptor (hOT7T175, AXOR12 or GPR54). Binds with high affinity to rat and human KISS1 receptors with K_i values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Technical Data

M.Wt:

1302.45

Formula:

C₆₃H₈₃N₁₇O₁₄

Sequence:

YNWNSFGLRF

(Modifications: Phe-10 = C-terminal amide)

Solubility:

Soluble to 1 mg/ml in 20% acetonitrile / water

Storage:

Desiccate at -20°C

CAS No:

374675-21-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

Analog Available

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631. PMID: 11457843.

Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other G_q-coupled receptors. Biochem.Biophys.Res.Comm. 326 677.

Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol. Endocrinology 149 1979. PMID: 18162521.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

KISS-Derived Peptide (KISS1) Receptors

Peptide Receptors

Keywords: Kisspeptin 10 (human), supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10

Quick Order

Find multiple products by catalog number

Cancer Research Guide

Request your free copy

Highlights over 350 products for cancer research. Request a copy or view PDF today.

7-TM Receptor Signaling

Written by T. Kenakin et al

'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy