R&D Systems Inc. Tocris Bioscience Boston Biochem

Calcitriol

Cat. No. 2551

Calcitriol C27H44O3 [32222-06-3]

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Alternative Name: 1,25-Dihydroxyvitamin D3

Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol

Biological Activity

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data

M.Wt:
416.64
Formula:
C27H44O3
Solubility:
Soluble in DMSO and in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
32222-06-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. PMID: 11004217.

Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. PMID: 15026558.

Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589. PMID: 16873882.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Calcitriol, supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3

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