R&D Systems Inc. Tocris Bioscience Boston Biochem

Calcitriol

Cat. No. 2551

Calcitriol C27H44O3 [32222-06-3]

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Alternative Name: 1,25-Dihydroxyvitamin D3

Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol

Biological Activity

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data

M.Wt:
416.64
Formula:
C27H44O3
Solubility:
Soluble in DMSO and in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
32222-06-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. PMID: 11004217.

Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. PMID: 15026558.

Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589. PMID: 16873882.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Calcitriol, supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3

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