Cat. No. 2551
Alternative Name: 1,25-Dihydroxyvitamin D3
Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,1
Biological ActivityActive metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. PMID: 11004217.
Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. PMID: 15026558.
Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589. PMID: 16873882.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: Calcitriol, supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3
Find multiple products by catalog number
New Products in this Area
Selective RARβ agonistSR 2211
Selective RORγ inverse agonistSR 1001
RORα/γ inverse agonistSR 1078
Prodrug of the antitumor agent 5F 203
Win a Kindle
March 18 - 21, 2014
University of Regensburg, Germany
Booth Number: 44