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Bay 59-3074

Cat. No. 2500

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Chemical Name: 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl 4,4,4-trifluoro-1-butanesulfonic acid ester

Biological Activity

Novel CB₁/CB₂ receptor partial agonist (K_i values are 48.3 and 45.5 nM at human CB₁ and CB₂ receptors respectively). Orally active CB₁ agonist in vivo. Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.

Licensing Information

Sold for research purposes under agreement from Bayer

Technical Data

M.Wt:

453.35

Formula:

C₁₈H₁₃F₆NO₄S

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

406205-74-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

De Vry et al (2004) 3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl-4,4,4-trifluoro-1-butanesulfonate (BAY 59-3074): a novel cannabinoid CB₁/CB₂ receptor partial agonist with antihyperalgesic and antiallodynic effects. J.Pharmacol.Exp.Ther. 310 620. PMID: 15140913.

De Vry et al (2004) Discriminative stimulus effects of the structurally novel cannabinoid CB₁/CB₂ receptor partial agonist BAY 59-3074 in the rat. Eur J Pharmacol. 505 127. PMID: 15556145.

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