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L-690,330Cat. No. 0681 |
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Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid |
Biological Activity
A potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.Licensing Information
Sold with the permission of Merck Sharp and Dohme Ltd.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
References
Atack et al (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 60 652. PMID: 8380439.
Atack et al (1994) Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 270 70. PMID: 8035344.
Sarkar et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 170 1101. PMID: 16186256.
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.
If you know of a relevant citation for this product please let us know.
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Keywords: L-690,330, supplier, Inositol, monophosphatase, inhibitors, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690330
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