Cat. No. 0681
Chemical Name: [1-(4-Hydroxyphenoxy)ethylidene]bisphosphonic acid
Biological ActivityA potent inhibitor of inositol monophophatase; stable to hydrolysis. Induces autophagy in COS-7 cells independently of mTOR inhibition.
Licensing InformationSold with the permission of Merck Sharp and Dohme Ltd.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Atack et al (1993) In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J.Neurochem. 60 652. PMID: 8380439.
Atack et al (1994) Effects of L-690,488, a pro-drug of the bisphosphonate inisotol monophosphatase inhibitor L-690,330, on phosphatidylinisotol cycle markers. J.Pharmacol.Exp.Ther. 270 70. PMID: 8035344.
Sarkar et al (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J.Cell.Biol. 170 1101. PMID: 16186256.
Fleming et al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 7 9. PMID: 21164513.
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Keywords: L-690,330, supplier, Inositol, monophosphatase, inhibitors, PIP2, Lipids, Ins145P3, 5-Phosphatase, IMPase, Phosphatases, L690330
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