R&D Systems Inc. Tocris Bioscience Boston Biochem

RITA

Cat. No. 2443

RITA C14H12O3S2 [213261-59-7]

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Alternative Name: NSC 652287

Chemical Name: 5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol

Biological Activity

Anti-tumor agent that binds wild-type p53 (Kd = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.

Technical Data

M.Wt:
292.37
Formula:
C14H12O3S2
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
213261-59-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Rivera et al (1999) Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Biochem.Pharmacol. 57 1283. PMID: 10230772.

Issaeva et al (2004) Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours. Nature Med. 10 1321.

Espinoza-Fonseca (2005) Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer. Theor.Biol.Med.Mod. 2 38.

Zhao et al (2010) Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 70 3372. PMID: 20395210.

If you know of a relevant citation for this product please let us know.

Keywords: RITA, supplier, p53-MDM2, interaction, inhibitors, antitumor, agent, MDM2-p53, MDM2, p14ARF, p53, Ligases, Transcription, Factors, NSC652287

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