R&D Systems Inc. Tocris Bioscience Boston Biochem

L-759,633

Cat. No. 2433

L-759633 C26H40O2 [174627-50-0]

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Chemical Name: (6aR,10aR)-3-(1,1-Dimethylheptyl)-6­a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H­-dibenzo[b,d]pyran

Biological Activity

High affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).

Technical Data

M.Wt:
384.59
Formula:
C26H40O2
Solubility:
Soluble to 25 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
174627-50-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Huffman et al (1999) 3-(1',1'-dimethylbutyl)-1-deoxy-D8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905. PMID: 10658595.

Ross et al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665. PMID: 10188977.

Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6 1323.

If you know of a relevant citation for this product please let us know.

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