Cat. No. 2433
Chemical Name: (6aR,10aR)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-methoxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
Biological ActivityHigh affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Huffman et al (1999) 3-(1',1'-dimethylbutyl)-1-deoxy-D8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905. PMID: 10658595.
Ross et al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665. PMID: 10188977.
Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 6 1323.
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Keywords: L-759633, supplier, High, affinity, selective, CB2, agonists, cannabinoids, Receptors, cb2r, L759633
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