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Amyloid β-peptide (1-40) (rat)

Cat. No. 2424

Amyloid b-peptide (1-40) (rat) Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

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Biological Activity

Rat form of the amyloid β-peptide found in plaques associated with Alzheimer's disease. Shown to have both neurotrophic and neurotoxic effects.

Technical Data

M.Wt:

4233.76

Formula:

C₁₉₀H₂₉₁N₅₁O₅₇S

Sequence:

DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV

Solubility:

Soluble to 1 mg/ml in 10% DMSO / water

Storage:

Desiccate at -20°C

CAS No:

144409-98-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Yankner et al (1990) Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 250 279. PMID: 2218531.

Kowalska and Badellino (1994) β-Amyloid protein induces platelet aggregation and supports platelet adhesion. Biochem.Biophys.Res.Comm. 205 1829.

Cleary et al (1995) Beta-amyloid(1-40) effects on behavior and memory. Brain Res. 682 69. PMID: 7552329.

Miguel-Hidalgo and Cacabelos (1998) Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. Acta Neuropathol. 95 455. PMID: 9600591.

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