R&D Systems Inc. Tocris Bioscience Boston Biochem

DAPTA

Cat. No. 2423

DAPTA D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2

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Alternative Name: D-Ala-peptide T-amide

Biological Activity

Chemokine receptor 5 (CCR5) antagonist. Acts as a selective antiviral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Technical Data

M.Wt:
856.89
Formula:
C35H56N10O15
Sequence:
ASTTTNYT

(Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
106362-34-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Ruff et al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51. PMID: 15043212.

Polianova et al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83. PMID: 16002156.

Rosi et al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671. PMID: 15979806.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: DAPTA, supplier, Chemokine, receptor, 5, CCR5, antagonists, CXCR, Receptors, antiviral

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