DAPTA

Cat. No. 2423

DAPTA D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2

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Alternative Name: D-Ala-peptide T-amide

Biological Activity

Chemokine receptor 5 (CCR5) antagonist. Acts as a selective viral entry inhibitor for R5 tropic HIV-1 strains. Blocks CCR5-mediated monocyte chemotaxis and reduces microglia and astrocyte activation in a neuroinflammatory rat model of Alzheimer's disease.

Technical Data

M.Wt:
856.89
Formula:
C35H56N10O15
Sequence:
ASTTTNYT

(Modifications: Ala-1 = D-Ala, Thr-8 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
106362-34-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Ruff et al (2003) Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors. Curr.HIV.Res. 1 51. PMID: 15043212.

Polianova et al (2005) Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 67 83. PMID: 16002156.

Rosi et al (2005) Chemokine receptor 5 antagonist D-Ala-peptide T-amide reduces microglia and astrocyte activation within the hippocampus in a neuroinflammatory rat model of Alzheimer's disease. Neuroscience 134 671. PMID: 15979806.

If you know of a relevant citation for this product please let us know.

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Keywords: DAPTA, supplier, Chemokine, receptor, 5, CCR5, antagonists, CXCR, Receptors, antiviral, Rantes, Tocris Bioscience, Chemokine Receptor Antagonists

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