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[Pyr¹]-Apelin-13

Cat. No. 2420

[Pyr1]-Apelin-13 pGlu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe

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Alternative Name: [pGlu¹]-Apelin-13

Biological Activity

Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC₅₀ = 0.37 nM) that displays potent vascular effects in vivo.

Technical Data

M.Wt:

1533.81

Formula:

C₆₉H₁₀₈N₂₂O₁₆S

Sequence:

XRPRLSHKGPMPF

(Modifications: X = pGlu)

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

217082-60-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471.

Katugampola et al (2001) [¹²⁵I]-(Pyr¹)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255. PMID: 11250876.

Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55. PMID: 15582714.

Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198. PMID: 15907343.

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7-TM Receptor Signaling

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'Seven Transmembrane Receptor Signaling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy