R&D Systems Inc. Tocris Bioscience Boston Biochem

KN-93

Cat. No. 1278

KN-93 C26H29ClN2O4S [139298-40-1]

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Chemical Name: N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide

Biological Activity

Potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for Kv1.5); independent of CaM kinase II inhibition.

Technical Data

M.Wt:
501.04
Formula:
C26H29ClN2O4S
Solubility:
Soluble to 100 mM in DMSO with gentle warming
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
139298-40-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Sumi et al (1991) The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine content in PC12h cells. Biochem.Biophys.Res.Comm. 181 968.

Anderson et al (1998) KN-93, an inhibitor of multifunctional Ca2+/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J.Pharmacol.Exp.Ther. 287 996. PMID: 9864285.

Patel et al (1999) Calcium/calmodulin-dependent phosphorylation and activation of human Cdc25-C at the G2/M phase transition in HeLa cells. J.Biol.Chem. 274 7958. PMID: 10075693.

Rezazadeh et al (2006) KN-93 (2-[N-(2-Hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 317 292. PMID: 16368898.

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Keywords: KN-93, supplier, K+, channel, blockers, KV, inhibitors, Potassium, Channels, voltage-gated, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Protein, Ca2+, Binding, modulators, Calcium, Signaling, Signalling, hERG, Human, Ether-A-Go-Go, Gene, KCNQ

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