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trans-4-Hydroxycrotonic acid

Cat. No. 0538

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Chemical Name: trans-4-Hydroxy-2-butenoic acid

Biological Activity

Binds to the γ-hydroxybutyric acid (GHB) receptor with higher affinity than GHB itself.� May be an endogenous ligand.

Technical Data

M.Wt:

102.09

Formula:

C₄H₆O₃

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

24587-49-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Vayer et al (1985) Natural occurrence of trans-gamma hydroxycrotonic acid in rat brain. Biochem.Pharmacol. 34 2401. PMID: 4015683.

Bourguignon et al (1988) Analogues of γ-hydroxybutyric acid. Synthesis and binding studies. J.Med.Chem. 31 893. PMID: 3361576.

Hechler et al (1993) Gamma hydroxybutyrate ligands posses antidopaminergic and neuroleptic-like activities. J.Pharmacol.Exp.Ther. 264 1406. PMID: 8095552.

If you know of a relevant citation for this product please let us know.

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