Cat. No. 2347

Salubrinal C21H17N4OSCl3 [405060-95-9]

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Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935. PMID: 15705855.

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849. PMID: 16002288.

If you know of a relevant citation for this product please let us know.

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Keywords: Salubrinal, supplier, Selective, inhibitors, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis, Protein Ser/Thr Phosphatase Inhibitors

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