R&D Systems Inc. Tocris Bioscience Boston Biochem

Salubrinal

Cat. No. 2347

Salubrinal C21H17N4OSCl3 [405060-95-9]

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Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).

Technical Data

M.Wt:
479.81
Formula:
C21H17N4OSCl3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
405060-95-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935. PMID: 15705855.

Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849. PMID: 16002288.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Salubrinal, supplier, Selective, inhibitors, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis

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