Cat. No. 2347
Chemical Name: 3-Phenyl-N-[2,2,2-trichloro-1-[[(8-
Biological ActivityCell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC50 ~ 15 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Boyce et al (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress. Science 307 935. PMID: 15705855.
Long et al (2005) Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. Bioorg.Med.Chem.Lett. 15 3849. PMID: 16002288.
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Keywords: Salubrinal, supplier, Selective, inhibitors, eIF2alpha, dephosphorylation, cellular, phosphatases, protein, synthesis, Protein Ser/Thr Phosphatase Inhibitors