WIN 55,212-3 mesylate
Cat. No. 2327
Alternative Name: (S)-(-)-WIN 55,212
Chemical Name: [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate
Biological ActivityNovel, low potency CB2 receptor silent antagonist and CB1 receptor partial inverse agonist. Competitively antagonizes effects of CP 55,940 (pA2 = 6.1) and SR 144528 (pEC50 = 5.3) at CB2 receptors and acts as a partial inverse agonist at CB1 receptors (pIC50 = 5.5). Displays modest activity at human melatonin MT1 and muscarinic M4 receptors, but is selective over several other GPCRs.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br.J.Pharmacol. 145 636. PMID: 15852035.
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Keywords: WIN 55212-3 mesylate, supplier, CB2, antagonists, CB1, partial, inverse, agonists, cannabinoids, Non-Selective, Receptors, WIN552123, mesylate, (S)-(-)-WIN55212, cb2r, cb1r
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