Home » Product Type » Controlled Substances » WIN 55,212-3 mesylate

WIN 55,212-3 mesylate

Cat. No. 2327

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Alternative Name: (S)-(-)-WIN 55,212

Chemical Name: [(3S)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone monomethanesulfonate

Biological Activity

Novel, low potency CB₂ receptor silent antagonist and CB₁ receptor partial inverse agonist. Competitively antagonizes effects of CP 55,940 (pA₂ = 6.1) and SR 144528 (pEC₅₀ = 5.3) at CB₂ receptors and acts as a partial inverse agonist at CB₁ receptors (pIC₅₀ = 5.5). Displays modest activity at human melatonin MT₁ and muscarinic M₄ receptors, but is selective over several other GPCRs.

Technical Data

M.Wt:

522.61

Formula:

C₂₇H₂₆N₂O₃.CH₃SO₃H

Solubility:

Soluble to 100 mM in DMSO with gentle warming

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

131543-25-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Other Information

R-enantiomer Available

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB₂ receptor. Br.J.Pharmacol. 145 636. PMID: 15852035.

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