QX 314 chloride

Cat. No. 2313

QX 314 chloride C16H27N2OCl [5369-03-9]

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Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37. PMID: 4541340.

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320. PMID: 8205485.

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911.

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Keywords: QX 314 chloride, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride, Voltage-gated Sodium (NaV) Channel Blockers

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