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QX 314 chloride

Cat. No. 2313

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Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

Biological Activity

Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na⁺ channels.

Technical Data

M.Wt:

298.85

Formula:

C₁₆H₂₇N₂OCl

Solubility:

Soluble to 100 mM in water

Purity:

>99 %

Storage:

Store at RT

CAS No:

5369-03-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Stichartz et al (1973) The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 62 37. PMID: 4541340.

Alreja and Aghajanian (1994) QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 639 320. PMID: 8205485.

Perkins and Wong (1995) Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 72 911.

If you know of a relevant citation for this product please let us know.

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Keywords: QX 314 chloride, supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, QX314, chloride

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