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Flunarizine dihydrochloride

Cat. No. 0522

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Chemical Name: (E)-1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

Biological Activity

Dual Na⁺/Ca²⁺ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Technical Data

M.Wt:

477.42

Formula:

C₂₆H₂₆F₂N₂.2HCl

Solubility:

Soluble to 5 mM in ethanol and to 50 mM in DMSO

Storage:

Desiccate at RT

CAS No:

30484-77-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Pauwels et al (1991) Ca⁺ and Na⁺ channels involved in neuronal cell death - protection by flunarizine. Life.Sci. 48 1881. PMID: 1850815.

Eichler et al (1994) The ability of diphenylpiperazines to prevent neuronal death in dorsal root ganglion neurons in vitro after axotomy. J.Neurochem. 62 2148. PMID: 8189223.

Urenjak and Obrenovitch (1996) Pharmacological modulation of voltage gated Na⁺ channels: a rational and effective strategy against ischemic brain damage. Pharmacol.Rev. 48 21. PMID: 8685246.

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